High-resolution optical coherence tomography imaging for high-precision surgery

We developed a novel platform based on a tele-operated robot to perform high-resolution optical coherence tomography (OCT) imaging under continuous large field-of-view magnetic resonance imaging (MRI) guidance. Intra-operative MRI (iMRI) is a promising guidance tool for high-precision surgery, but it may not have sufficient resolution or contrast to visualize certain small targets. To address these limitations, we developed an MRI-compatible OCT needle probe, which is capable of providing microscale tissue architecture in conjunction with macroscale MRI tissue morphology in real time. Co-registered MRI/OCT images demonstrated that the complementary imaging scales and contrast mechanisms have great potential to improve the efficiency and the accuracy of iMRI procedure.

C.P. Liang, B. Yang, I.K. Kim, G. Makris, J.P. Desai, R.P. Gullapalli, Y. Chen*, “Concurrent Multiscale Imaging with Magnetic Resonance Imaging and Optical Coherence Tomography,” Journal of Biomedical Optics, 18, 046015 (2013).

Yu Chen, Fischell Department of Bioengineering