Muro, Silvia

Silvia Muro
Associate Professor
Fischell Department of Bioengineering
Institute for Bioscience and Biotechnology Research
A. James Clark School of Engineering
5143 Plant Sciences Building
General Research Interests: 
  • Mechanisms of endocytic vesicular transport
The Muro Group studies mechanisms of endocytic vesicular transport, including their role in physiology and disease, and their translational application for the controlled delivery of nano-scale imaging and therapeutic agents to precise targets in the body, at the tissue, cell, and subcellular levels. Particular emphasis is given to the design of nanovehicles that improve the transport of pharmaceuticals and biologicals across the blood-brain barrier that separates the bloodstream from the central nervous system, and those that further allow efficient delivery into neurons. As an illustration of the therapeutic potential of these platforms, the Muro Group pursues treatment of neurodegenerative conditions caused by genetic defects of lysosomal enzymes, for which enzyme replacement therapies are being designed and tested in vitro, cell culture, and animal models.

Dr. Muro received her PhD in Sciences - Molecular Biology from the University Autonoma of Madrid, Spain, in 1999. She had an extensive training in medical, biomolecular, and drug targeting research including fellowships and postdoctoral appointments in Spain, Canada, Denmark and the School of Medicine of the University of Pennsylvania in USA. She joined the University of Maryland at College Park in 2008, where she is currently an Associate Professor in the with a joint appointment in the Fischell Department of Bioengineering and the Institute for Bioscience and Biotechnology Research. Dr. Muro and her group have received recognitions by the Controlled Release Society, the American Society for Nanomedicine, the World Organization for Rare Lysosomal Disorders, the Society for the Study of Inborn Errors of Metabolism, and others. She received the UMD Outstanding Life Sciences Invention of the Year award in 2011 and the Junior Faculty Outstanding Engineering Research award in 2012. Dr. Muro is currently a standing member of the NIH Nanotechnology (NANO) Study Section.