Faculty Directory

Sriram, Ganesh

Sriram, Ganesh

Associate Professor
Keystone Professor
Associate Chair and Undergraduate Program Director
Chemical and Biomolecular Engineering
Maryland Energy Innovation Institute
Brain and Behavior Institute
4418 Stadium Dr. 1208D
Website(s):

EDUCATION

Ph.D., Iowa State University, 2004

BACKGROUND

Dr. Ganesh Sriram is Associate Professor and Keystone Professor in the Department of Chemical and Biomolecular Engineering at University of Maryland. After earning his bachelor's and master's degrees in chemical engineering from Indian Institute of Technology (IIT) Bombay, he graduated a Ph.D. in chemical engineering from Iowa State University in 2004, working in the lab of Dr. Jacqueline Shanks. From 2004 to 2007, he was a postdoctoral researcher in the labs of Dr. Katrina Dipple and Dr. James Liao at UCLA.

SELECTED HONORS AND AWARDS

  • Poole & Kent Teaching Award for Senior Faculty, A. James Clark School of Engineering, University of Maryland, 2022
  • Keystone Professorship, A. James Clark School of Engineering, University of Maryland, 2011
  • Outstanding Young Engineer Award and Allan C. Davis Medal, Maryland Academy of Sciences and Maryland Science Center, 2011
  • Samuel Roberts Noble Foundation Best Presentation Award, Third International Congress on Plant Metabolomics, 2004
  • Metabolic Engineering III Fellowship, Engineering Conferences International, 2000
  • Best Innovative Potential Master’s Thesis Award, Indian National Academy of Engineering, 1999

PROFESSIONAL MEMBERSHIPS

  • Sigma Xi, The Scientific Research Society
  • American Institute of Chemical Engineers
  • American Chemical Society
  • American Society of Plant Biologists

 

Systems biology and metabolic engineering (metabolic networks, regulatory networks, fuel production from biorenewable resources); genetically inherited metabolic disorders.


The Sriram Lab's research is focused on two related areas: metabolic engineering and systems biology, especially of eukaryotes. The group's  specialties are metabolic flux analysis and gene regulatory network analysis. Toward performing such analyses, the group combines experimental methods such as isotope labeling, two-dimensional (2-D) NMR, gas chromatography-mass spectrometry (GC-MS), DNA microarray analysis and quantitative RT-PCR (qPCR) together with computational methods.

For more information, please visit Professor Sriram's web site.

Professor Sriram currently teaches or has taught the following courses:

  • BIOE 120: Biology for Engineers
  • CHBE100: Exploring ChBE (Co-Instructor)
  • CHBE101/ENCH 215: Introduction to Chemical and Biomolecular Engineering
  • CHBE301/ENCH 300: Chemical Process Thermodynamics
  • CHBE444: Process Economics and Design I
  • CHBE484/ENCH 468M/BIOE 489L/ENCH648M: Metabolic Pathway Engineering

  • Lugar DJ, Sriram G. Isotope-assisted metabolic flux analysis as an equality-constrained nonlinear program for improved scalability and robustness. PLOS Computational Biology. 2022;18: e1009831. doi:10.1371/journal.pcbi.1009831
  • Goldberg DS, Sriram G. Assessment of short and longer-term impacts of a 1-credit chemical engineering first-year seminar. Chemical Engineering Education. 2021 [cited 22 May 2022]. doi:10.18260/2-1-370.660-129531
  • Moiz B, Garcia J, Basehore S, Sun A, Li A, Padmanabhan S, et al. 13C metabolic flux analysis indicates endothelial cells attenuate metabolic perturbations by modulating TCA activity. Metabolites. 2021;11: 226. doi:10.3390/metabo11040226
  • Sittmann J, Bae M, Mevers E, Li M, Quinn A, Sriram G, et al. Bacterial diketopiperazines stimulate diatom growth and lipid accumulation. Plant Physiology. 2021;186: 1159–1170. doi:10.1093/plphys/kiab080
  • Mack SG, Sriram G. NetFlow: A tool for isolating carbon flows in genome-scale metabolic networks. Metabolic Engineering Communications. 2021;12: e00154. doi:10.1016/j.mec.2020.e00154
  • Lugar DJ, Mack SG, Sriram G. NetRed, an algorithm to reduce genome-scale metabolic networks and facilitate the analysis of flux predictions. Metabolic Engineering. 2021;65: 207–222. doi:10.1016/j.ymben.2020.11.003
  • Chung J, Sriram G, Keefer CL. Nanoparticle technology improves in-vitro attachment of cattle (Bos taurus) trophectoderm cells. Biotechnol Lett. 2020;42: 2083–2089. doi:10.1007/s10529-020-02926-w
  • Zhang X, Misra A, Nargund S, Coleman GD, Sriram G. Concurrent isotope-assisted metabolic flux analysis and transcriptome profiling reveal responses of poplar cells to altered nitrogen and carbon supply. Plant J. 2018;93: 472–488. doi:10.1111/tpj.13792
  • Parr LS, Sriram G, Nazarian R, Rahib L, Dipple KM. The ATP-stimulated translocation promoter (ASTP) activity of glycerol kinase plays central role in adipogenesis. Molecular Genetics and Metabolism. 2018;124: 254–265. doi:10.1016/j.ymgme.2018.06.001
  • Ho CK, Sriram G, Dipple KM. Insulin sensitivity predictions in individuals with obesity and type II diabetes mellitus using mathematical model of the insulin signal transduction pathway. Molecular Genetics and Metabolism. 2016;119: 288–292. doi:10/gdq92s
  • Ho CK, Rahib L, Liao JC, Sriram G, Dipple KM. Mathematical modeling of the insulin signal transduction pathway for prediction of insulin sensitivity from expression data. Molecular Genetics and Metabolism. 2015;114: 66–72. doi:10/gdq92r
  • Islam N, Li G, Garrett WM, Lin R, Sriram G, Cooper B, et al. Proteomics of nitrogen remobilization in poplar bark. J Proteome Res. 2015;14: 1112–1126. doi:10.1021/pr501090p
  • Nargund S, Misra A, Zhang X, Coleman GD, Sriram G. Flux and reflux: Metabolite reflux in plant suspension cells and its implications on isotope-assisted metabolic flux analysis. Mol BioSyst. 2014;10: 1496–1508. doi:10.1039/C3MB70348G
  • Zheng Y, Quinn AH, Sriram G. Experimental evidence and isotopomer analysis of mixotrophic glucose metabolism in the marine diatom Phaeodactylum tricornutum. Microbial Cell Factories. 2013;12: 109. doi:10.1186/1475-2859-12-109

Do Suddenly Self-Centered Brain Cells Promote Disease?

NSF Award Funds UMD Alzheimer’s Research Into Brain Glucose Metabolism

$7.9 Million in NIH Awards Propel UMD Aging Research

New multidisciplinary collaborations take on challenges like Alzheimer’s disease prevention.

Research Finds that Exercise Can Change Brain Structure in Healthy Older Adults

A new study used diffusion imaging to measure the microstructure and tissue composition in the hippocampus after 30 minutes of exercise.

BBI Awards Seed Grants to Six Interdisciplinary Projects

Funded teams feature UMD faculty from 15 academic departments and six centers and institutes